Table 5.
Association Between Imaging Measurements and Neurocognitive Impairment, Defined as a z-score <−1 in at Least Two Out of Seven Cognitive Domains: Logistic Regression Modelsa
| Overall Neurocognitive Impairment |
Symptomatic Neurocognitive Impairment |
|||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | |
| White matter hyperintensities | ||||||
| Lesion volume (log10)a | 1.0 | .9, 1.1 | .857 | 1.1 | 1.0, 1.2 | .266 |
| Atrophy scores | ||||||
| GCA | 1.2 | .6, 2.7 | .580 | 6.2 | 1.7, 22.3 | .005 |
| TLA | 1.3 | .6, 2.7 | .515 | 1.8 | .8, 4.4 | .173 |
| Bicaudate index | 1.1 | .6, 2.2 | .737 | 2.0 | .9, 4.4 | .100 |
| Single voxel MRS | ||||||
| NAA/Choa | 1.2 | .6, 2.6 | .590 | 1.9 | .8, 4.5 | .140 |
| NAA/Cra | 1.7 | .8, 3.4 | .164 | 1.9 | .9, 4.3 | .116 |
| mI/Cra | 1.0 | .5, 1.8 | .953 | 0.8 | .4, 1.5 | .454 |
Bolded text indicates the significant result.
Abbreviations: CI, confidence interval; GCA, Global cortical atrophy score; mI/Cr, Myo-inositol to creatine ratio; MRS, magnetic resonance spectroscopy; NAA/Cho, N-acetyl aspartate to choline ratio; NAA/Cr, N-acetyl aspartate to creatine ratio; OR, odds ratio; TLA, Medial temporal lobe atrophy score.
a Adjusted for study arm allocation, age (per additional year), ethnicity (black vs other), education (per additional year on formal education) and nadir CD4 count (per 100c more).