Table 4.
Anti-cancer data
| 1° Screening | Prostate DU-145 (μM) |
Ovary IGROV-ET (μM) |
Breast SK-BR3 (μM) |
Melanoma SK-MEL-28 (μM) |
Lung A549 (μM) |
Leukemia K-562 (μM) |
Pancreas PANC1 (μM) |
Colon LOVO (μM) |
Cervix HELA-APL (μM) |
|
|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GI50 | >28.9 | 13.8 | >28.9 | 15.9 | >28.9 | 15.0 | 8.5 | 10.4 | 14.3 |
| TGI | >28.9 | >28.9 | >28.9 | >28.9 | >28.9 | 20.2 | 24.3 | 28.9 | >28.9 | |
| LC50 | >28.9 | >28.9 | >28.9 | >28.9 | >28.9 | 27.0 | 28.9 | >28.9 | >28.9 | |
| 4 | GI50 | 5.4 | 4.1 | 7.3 | 5.3 | 5.5 | 6.0 | 3.2 | 4.3 | 4.8 |
| TGI | 9.2 | 8.4 | 14.4 | 9.1 | 9.5 | 9.6 | 6.6 | 8.3 | 8.9 | |
| LC50 | 15.8 | 17.1 | 17.8 | 15.5 | 16.5 | 15.3 | 13.4 | 16.3 | 16.5 | |
| 5 | GI50 | 13.5 | 9.6 | 9.4 | 7.5 | 9.6 | 10.0 | 4.8 | 5.1 | 6.9 |
| TGI | >28.5 | >28.5 | 20.8 | 23.2 | 25.2 | 14.3 | 9.3 | 11.9 | 17.9 | |
| LC50 | >28.5 | >28.5 | >28.5 | >28.5 | >28.5 | 20.3 | 18.3 | 27.6 | >28.5 | |
| 6 | GI50 | 15.8 | 10.7 | 9.3 | 4.8 | 12.2 | 7.1 | 5.1 | 4.9 | 10.0 |
| TGI | >27.1 | >27.1 | 18.3 | 9.1 | >27.1 | 11.0 | 10.8 | 11.4 | 27.1 | |
| LC50 | >27.1 | >27.1 | >27.1 | 17.1 | >27.1 | 17.1 | 23.1 | 26.4 | >27.1 | |
| 7 | GI50 | 6.9 | 5.7 | 6.2 | 4.9 | 6.1 | 8.8 | 4.6 | 4.6 | 5.7 |
| TGI | 15.0 | 10.0 | 11.0 | 8.4 | 12.5 | 12.5 | 8.3 | 8.3 | 10.8 | |
| LC50 | >27.1 | 17.4 | 19.5 | 14.3 | 25.4 | 17.9 | 15.0 | 14.9 | 20.2 | |
| 8 | GI50 | >30.5 | 25.7 | >30.5 | 29.4 | >30.5 | 26.5 | 14.1 | 18.1 | 30.5 |
| TGI | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | |
| LC50 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | >30.5 | |
| 9 | GI50 | 8.3 | 9.2 | 10.4 | 5.6 | 9.6 | 7.9 | 5.4 | 7.5 | 6.8 |
| TGI | 18.9 | 18.2 | >26.4 | 9.5 | 26.4 | 11.8 | 9.3 | 15.2 | 12.4 | |
| LC50 | >26.4 | >26.4 | >26.4 | 16.2 | >26.4 | 17.9 | 16.0 | >26.4 | 22.7 | |
| 10 | GI50 | 4.8 | 3.4 | 5.0 | 5.0 | 5.0 | 6.4 | 2.8 | 3.5 | 4.5 |
| TGI | 8.4 | 6.8 | 8.6 | 8.7 | 9.0 | 10.0 | 6.1 | 7.0 | 8.3 | |
| LC50 | 14.7 | 13.8 | 14.8 | 15.1 | 16.2 | 15.6 | 13.0 | 13.8 | 15.2 | |
| 11 | GI50 | 14.8 | 10.8 | 15.8 | 9.8 | >28.9 | 8.1 | 5.3 | 7.9 | 6.6 |
| TGI | >28.9 | >28.9 | >28.9 | 28.9 | >28.9 | 13.4 | 9.9 | 17.6 | 14.0 | |
| LC50 | >28.9 | >28.9 | >28.9 | >28.9 | >28.9 | 22.2 | 18.4 | >28.9 | 28.9 | |
| 12 | GI50 | 5.6 | 4.4 | 11.3 | 4.2 | 11.9 | 2.8 | 3.1 | 3.0 | 3.8 |
| TGI | 14,1 | 9.0 | 24.0 | 7.9 | >24.0 | 5.6 | 6.3 | 6.2 | 8.3 | |
| LC50 | >24.0 | 18.3 | >24.0 | 15.0 | >24.0 | 11.0 | 12.9 | 12.8 | 17.8 | |
| 13 | GI50 | 4.4 | 8.1 | 7.3 | 3.9 | 4.7 | 1.7 | 2.8 | 2.9 | 3.6 |
| TGI | 8.0 | 12.0 | 11.2 | 7.4 | 8.3 | 4.3 | 5.9 | 5.9 | 7.0 | |
| LC50 | 14.4 | 17.8 | 17.3 | 14.0 | 14.5 | 9.8 | 12.4 | 12.2 | 13.6 | |
| 14 | GI50 | 3.8 | 2.9 | 6.5 | 3.0 | 4.5 | 0.1 | 1.1 | 1.5 | 1.0 |
| TGI | 7.6 | 6.1 | 10.1 | 6.0 | 8.0 | 0.5 | 3.7 | 4.5 | 3.3 | |
| LC50 | 15.5 | 12.6 | 15.8 | 12.0 | 14.3 | 1.1 | 9.6 | 10.8 | 9.2 | |
| 15 | GI50 | >27.1 | 16.2 | 21.9 | 10.5 | 27.1 | 3.6 | 6.0 | 9.4 | 13.9 |
| TGI | >27.1 | >27.1 | >27.1 | 27.1 | >27.1 | 7.5 | 13.4 | 27.1 | >27.1 | |
| LC50 | >27.1 | >27.1 | >27.1 | >27.1 | >27.1 | 15.5 | >27.1 | >27.1 | >27.1 | |
| 16 | GI50 | 6.2 | 5.8 | 6.5 | 4.9 | 5.8 | 5.8 | 3.8 | 3.4 | 4.8 |
| TGI | 10.7 | 10.5 | 10.7 | 8.8 | 10.8 | 9.6 | 7.6 | 6.9 | 8.9 | |
| LC50 | 18.6 | 18.9 | 17.8 | 15.6 | 20.3 | 15.9 | 14.8 | 14.0 | 16.6 | |
| 17 | GI50 | 4.9 | 4.3 | 5.8 | 4.8 | 4.9 | 1.9 | 2.8 | 3.2 | 4.7 |
| TGI | 8.7 | 7.9 | 9.5 | 8.4 | 8.6 | 4.2 | 6.0 | 6.5 | 8.2 | |
| LC50 | 15.0 | 14.6 | 15.5 | 14.5 | 15.0 | 9.6 | 12.4 | 13.1 | 14.4 | |
| 18 | GI50 | >30.7 | 23.2 | >30.7 | 27.0 | 28.2 | >30.7 | 16.8 | 12.3 | 30.7 |
| TGI | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | |
| LC50 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | >30.7 | |
| 19 | GI50 | 3.6 | 9.1 | 5.6 | 3.7 | 7.4 | 5.7 | 3.1 | 3.2 | 3.6 |
| TGI | 6.4 | >20.3 | 10.2 | 6.5 | 20.3 | 8.6 | 5.8 | 5.9 | 6.6 | |
| LC50 | 11.3 | >20.3 | 18.4 | 11.4 | >20.3 | 13.0 | 10.8 | 10.9 | 11.9 | |
| 20 | GI50 | 9.1 | 4.9 | 6.9 | 4.8 | 6.1 | 4.4 | 4.4 | 4.5 | 4.9 |
| TGI | 24.3 | 8.9 | 12.1 | 8.7 | 10.9 | 8.0 | 8.3 | 8.1 | 8.9 | |
| LC50 | >28.0 | 16.2 | 21.1 | 15.5 | 19.3 | 14.6 | 15.6 | 14.6 | 16.3 | |
| 21 | GI50 | 19.5 | 11.0 | >27.6 | 6.1 | 20.8 | 6.7 | 5.2 | 5.0 | 5.7 |
| TGI | >27.6 | 25.6 | >27.6 | 11.5 | >27.6 | 12.6 | 10.5 | 9.4 | 10.4 | |
| LC50 | >27.6 | >27.6 | >27.6 | 21.6 | >27.6 | 23.8 | 21.2 | 17.7 | 18.9 | |
GI50 is the concentration at which 50% growth inhibition was observed. TGI is the concentration at which total growth inhibition was observed. LC50 is the lethal concentration at which 50% cell death occurred.