Table 2. . Quadratic regression models for DNA methylation variance and average methylation at individual CpG sites in CD4+ T cells.
|
Genes |
Q or L fit |
p-value of interaction terms |
Difference between control and TCE? |
|
|---|---|---|---|---|
| Control | TCE | |||
|
Effector/memory | ||||
|
Cd70 |
Q |
Q |
<0.001 |
Y |
|
Lif |
Q |
Q |
0.21 |
N |
|
Tnf |
Q |
Q |
<0.01 |
Y |
|
Il4 |
Q |
Q |
0.46 |
N |
|
Cdkn1a |
Q |
Q |
0.05 |
N |
|
Dnmt3a |
Q |
Q |
<0.001 |
Y |
|
Ctla4 |
Q |
Q |
0.02 |
Y |
|
Ifng |
L |
L |
0.32 |
N |
|
Naive | ||||
|
Cd70 |
L |
Q |
<0.001 |
Y |
|
Lif |
Q |
Q |
0.01 |
Y |
|
Tnf |
Q |
Q |
<0.001 |
Y |
|
Il4 |
Q |
Q |
0.04 |
Y |
|
Cdkn1a |
Q |
Q |
<0.001 |
Y |
|
Dnmt3a |
Q |
Q |
<0.001 |
Y |
|
Ctla4 |
Q |
Q |
0.06 |
N |
| Ifng | L | L | 0.16 | N |
L: Linear; TCE: Trichloroethylene; Q: Quadratic.