Table 1. Gene Alterations.
Somatic tumor gene alterations
| Gene | Chromosome | Alteration | Copy number change |
|---|---|---|---|
| EZH2 | 7q36.1 | Amplification | 3.7 |
| MLL3 | 7q36.1 | Amplification | 2.6 |
| IDH1 | 2q34 | Deletion | −6.4 |
| ERBB4 | 2q34 | Deletion | −6.4 |
| RB1 | 13q14.2 | Deletion | −2.7 |
| PTCH1 | 9q22.32 | Deletion | −2.2 |
| FGFR1 | 8p11.22 | Deletion | −2.2 |
| SUZ12 | 17q11.2 | Deletion | −2.2 |
| NF1 | 17q11.2 | Deletion | −2.1 |
| CTLA4 | 2q33.2 | Deletion | −2 |
| BARD1 | 2q35 | Deletion | −2 |
| CUL3 | 2q36.2 | Deletion | −2 |
| IRS1 | 2q36.3 | Deletion | −2 |
| PDCD1 | 2q37.3 | Deletion | −2 |
| ATRX | Xq21.1 | Loss | −1.9 |
| FANCC | 9q22.32 | Deletion | Intragenic |
| JAK3 | 19p13 | Inversion | g.5361328_c.1914+13 |
| Germlinegene alterations of unknown significance | |||
| PARP1 | p.W481C | ||
| RECQL4 | p.D1121N | ||
| AMER1 | p.E385Q | ||
| FOXP1 | p.A15V | ||