Figure 2.

In vitro cell-protective effects of B-ring dioxane and B-ring pyran bryostatin analogues against CHIKV (full structure provided in Figure 1). ^aSee Figure 1 for a description of EC₅₀ and CC₅₀ values; standard deviations for all values can be found in the Supporting Information. ^bNote that bryostatin 1 (1) contains a slightly different southern fragment than the analogues above, namely, the C-20 octadienoate (rather than octanoate) and the presence of a C-26 methyl group. ^cValues in italics indicate that toxicity was observed before the EC₅₀ value could be generated.