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Trends in CHIKV inhibition as controlled through northern fragment substitution patterns of bryostatin-like analogues. (Left) Trends observed based on B-ring functionality of B-ring dioxane and the pyran series. (Right) Effects of A-ring functionality with P representing potency (in terms of cell-protective effects) and T representing toxicity. See text and Figure 1 for description of EC50 and CC50 values.
