. Author manuscript; available in PMC: 2016 Jun 30.

Published in final edited form as: Pediatr Res. 2015 Apr 9;78(2):198–204. doi: 10.1038/pr.2015.72

Table 4.

Brain metrics and volumes

	High-dose caffeine (n = 28)	Standard-dose caffeine (n = 30)	P value
d-Bifrontal diameter	−15.0 ± 4.8	−14.7 ± 6.1	0.82
d-Brain biparietal diameter	−14.4 ± 4.4	−13.8 ± 4.4	0.61
Interhemispheric distance	3.8 ± 1.5	3.9 ± 1.8	0.73
d-Transverse cerebellar diameter	−0.3 ± 3.1	0.3 ± 2.8	0.52
Right ventricular diameter	7.8 ± 1.6	7.8 ± 1.9	0.95
Left ventricular diameter	8.2 ± 2.1	8.2 ± 1.6	0.91
White matter volume^a	136.7 ± 26.7	127.8 ± 13.1	0.36
Gray matter volume^a	104.3 ± 14.4	103.9 ± 26.7	0.97
Deep nuclear gray matter volume^a	23.0 ± 2.2	22.1 ± 2.2	0.39
Cerebellar volume^a	18.7 ± 4.1	16.2 ± 2.4	0.13
Cerebrospinal fluid volume^a	109.4 ± 37.3	104.6 ± 17.2	0.72

Values represent mean ± SD

Volumetric analysis completed in infants with scans of sufficient quality for accurate segmentation (8 high-dose infants and 10 standard-dose infants)