Table 5.
Diffusion
| Apparent diffusion coefficient | Fractional anisotropy | |||||
|---|---|---|---|---|---|---|
| High-dose caffeine (n = 25) | Standard caffeine (n = 27) | P value | High-dose caffeine (n = 25) | Standard caffeine (n = 27) | P value | |
| Right anterior limb of internal capsule | 1.43 ± 0.07 | 1.42 ± 0.09 | 0.68 | 0.30 ± 0.07 | 0.30 ± 0.05 | 0.81 |
| Left anterior limb of internal capsule | 1.42 ± 0.07 | 1.43 ± 0.07 | 0.68 | 0.29 ± 0.06 | 0.29 ± 0.07 | 0.84 |
| Right posterior limb of internal capsule | 1.23 ± 0.05 | 1.24 ± 0.05 | 0.67 | 0.51 ± 0.04 | 0.50 ± 0.04 | 0.44 |
| Left posterior limb of internal capsule | 1.23 ± 0.03 | 1.27 ± 0.06 | 0.10 | 0.49 ± 0.06 | 0.48 ± 0.06 | 0.30 |
| Right optic radiation | 1.54 ± 0.06 | 1.56 ± 0.10 | 0.50 | 0.34 ± 0.04 | 0.35 ± 0.05 | 0.57 |
| Left optic radiation | 1.57 ± 0.12 | 1.54 ± 0.11 | 0.30 | 0.35 ± 0.05 | 0.35 ± 0.05 | 0.88 |
| Right superior frontal lobe white matter | 1.70 ± 0.14 | 1.72 ± 0.15 | 0.64 | 0.14 ± 0.03 | 0.14 ± 0.03 | 0.69 |
| Left superior frontal lobe white matter | 1.72 ± 0.13 | 1.70 ± 0.13 | 0.60 | 0.14 ± 0.03 | 0.14 ± 0.03 | 0.76 |
| Corpus callosum | 1.58 ± 0.15 | 1.62 ± 0.24 | 0.47 | 0.49 ± 0.06 | 0.51 ± 0.07 | 0.31 |
| Right cingulum bundle | 1.49 ± 0.06 | 1.48 ± 0.06 | 0.49 | 0.32 ± 0.04 | 0.32 ± 0.05 | 0.64 |
| Left cingulum bundle | 1.49 ± 0.06 | 1.49 ± 0.06 | 0.99 | 0.34 ± 0.05 | 0.34 ± 0.05 | 0.90 |
| Right centrum semiovale | 1.76 ± 0.17 | 1.78 ± 0.15 | 0.77 | 0.15 ± 0.06 | 0.13 ± 0.05 | 0.26 |
| Left centrum semiovale | 1.75 ± 0.14 | 1.77 ± 0.14 | 0.61 | 0.14 ± 0.04 | 0.14 ± 0.05 | 0.67 |
| Right superior frontal gyrus gray matter | 1.66 ± 0.06 | 1.64 ± 0.06 | 0.16 | 0.14 ± 0.03 | 0.15 ± 0.02 | 0.39 |
| Left superior frontal gyrus gray matter | 1.66 ± 0.10 | 1.64 ± 0.08 | 0.27 | 0.15 ± 0.04 | 0.15 ± 0.03 | 0.47 |
| Right inferior frontal gyrus gray matter | 1.67 ± 0.06 | 1.67 ± 0.07 | 0.73 | 0.13 ± 0.04 | 0.13 ± 0.02 | 0.90 |
| Left inferior frontal gyrus gray matter | 1.68 ± 0.10 | 1.68 ± 0.09 | 0.98 | 0.14 ± 0.04 | 0.14 ± 0.03 | 0.68 |
| Right orbitofrontal cortex gray matter | 1.74 ± 0.11 | 1.77 ± 0.16 | 0.47 | 0.15 ± 0.05 | 0.14 ± 0.03 | 0.71 |
| Left orbitofrontal cortex gray matter | 1.75 ± 0.13 | 1.73 ± 0.10 | 0.47 | 0.15 ± 0.04 | 0.15 ± 0.04 | 0.90 |
| Right cerebellum | 1.34 ± 0.10 | 1.35 ± 0.12 | 0.77 | 0.19 ± 0.06 | 0.18 ± 0.04 | 0.54 |
| Left cerebellum | 1.36 ± 0.10 | 1.38 ± 0.14 | 0.68 | 0.19 ± 0.04 | 0.19 ± 0.04 | 0.61 |
Values represent mean ± SD