Table 1.
Diagnosis overview
| ICD-10 | Extracted diagnoses (%) | Herlev database | Primary review | Secondary review | Total verified |
|---|---|---|---|---|---|
| D550 – (G6PD) deficiency | – | 0 | 2 | 0 | 2 |
| D552 – (PK) deficiency | – | 0 | 1 | 0 | 1 |
| D56 – Thalassemia | 130 (31.55) | 8 | 20 | 8 | 36 |
| D560 – Alpha-thalassemia | – | 19 | 4 | 0 | 23 |
| D561 – Beta-thalassemia | – | 41 | 1 | 1 | 43 |
| D563 – Thalassemia trait | – | 0 | 5 | 0 | 5 |
| D57 – Sickle cell anemia | 25 (6.07) | 0 | 3 | 1 | 4 |
| D572 – Double heterozygous sickling disorders | – | 2 | 0 | 0 | 2 |
| D572a – Hb-SC disease | – | 4 | 1 | 0 | 5 |
| D572d – Sickle cell thalassemia | – | 5 | 1 | 0 | 6 |
| D573 – Heterozygous hemoglobin S | – | 6 | 0 | 0 | 6 |
| D580 – Hereditary spherocytosis (HS) | 72 (17.48) | – | – | – | – |
| D580 – HS, cat 0 | – | 0 | 36 | 8 | 44 |
| D580 – HS, cat 1a | – | 0 | 0 | 3 | 3 |
| D580 – HS, cat 1b | – | 0 | 0 | 2 | 2 |
| D580 – HS, cat 1c | – | 0 | 0 | 9 | 9 |
| D580 – HS, cat 2 | – | 0 | 0 | 7 | 7 |
| D581 – Hereditary elliptocytosis | 1 (0.24) | 0 | 1 | 0 | 1 |
| D582 – Other hemoglobinopathies | 2 (0.49) | 0 | 2 | 1 | 3 |
| D582e – Hb-E disease | – | 3 | 0 | 1 | 4 |
| D589 – Hereditary hemolytic anemia, unspecified | 19 (4.61) | 0 | 0 | 1 | 1 |
| D590 – Drug-induced AIHA | 5 (1.21) | 0 | 1 | 1 | 2 |
| D591 – AIHA, endogenous | 129 (31.31) | 0 | 80 | 15 | 95 |
| D591a – Cold agglutinin | 5 (1.21) | 0 | 16 | 3 | 19 |
| D592 – Drug-induced non-AIHA | 4 (0.97) | 0 | 1 | 1 | 2 |
| D594 – Other non-AIHA | 14 (3.40) | 0 | 7 | 1 | 8 |
| D594c – Toxic hemolytic anemia | 1 (0.24) | 0 | 0 | 0 | 0 |
| D595 – Paroxysmal nocturnal hemoglobinuria | 5 (1.21) | 0 | 4 | 0 | 4 |
| D599 – Acquired hemolytic anemia, unspecified | – | 0 | 9 | 9 | 18 |
| Uncertain diagnosis | – | 0 | 0 | 20 | 20 |
| No hemolytic disorder | – | 0 | 35 | 2 | 37 |
| Total | 412 | 88 | 230 | 94 | 412 |
Note: The lowercase suffix on D572, D582, D591, and D594 is a specific part of the Danish implementation of ICD-10.
Abbreviations: ICD-10, International Classification of Diseases Tenth Revision; G6PD, glucose-6-phosphate dehydrogenase; PK, pyruvate kinase; cat, category; AIHA, autoimmune hemolytic anemia; Hb-SC, sickle cell–haemoglobin C; Hb-E, hemoglobin E.