Table S1.
Summary of trough FEV1 at day 169 and SGRQ total score at day 168 in Study A (ITT population)
| Endpoint | UMEC/VI (n=413) | UMEC (n=418) | VI (n=421) | Placebo(n=280) |
|---|---|---|---|---|
| Trough FEV1 at day 169, n | 330 | 322 | 317 | 201 |
| LS mean (SE), L | 1.406 (0.0126) | 1.354 (0.0126) | 1.311 (0.0127) | 1.239 (0.0158) |
| LS mean change (SE), L | 0.171 (0.0126) | 0.119 (0.0126) | 0.076 (0.0127) | 0.004 (0.0158) |
| SGRQ total score at day 168, n | 317 | 312 | 304 | 192 |
| LS mean (SE) | 41.11 (0.749) | 41.93 (0.753) | 41.43 (0.760) | 46.62 (0.950) |
| LS mean change (SE) | −8.07 (0.749) | −7.25 (0.753) | −7.75 (0.760) | −2.56 (0.950) |
Abbreviations: FEV1, forced expiratory volume in 1 second; ITT, intent-to-treat; LS, least squares; SE, standard error; SGRQ, St George’s Respiratory Questionnaire; TIO, tiotropium; VI, vilanterol; UMEC, umeclidinium; L, liters.