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. 2016 Jun 24;9:3815–3827. doi: 10.2147/OTT.S100633

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© 2016 Fu et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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lncRNA AK126698 inhibits A549 cell proliferation and migration and induces apoptosis.

Notes: (A) A549 cells were transduced with Lv-AK126698 and Lv-AK126698-NC (control) viruses. Seventy-two hours after transduction, the expression of AK126698 was analyzed by qRT-PCR. (B) Cell viability was measured using the CCK-8 cell growth assay. (C) The effects of AK126698 on A549 cell proliferation were analyzed by EdU incorporation assay. The blue color indicates the nuclei and the red color represents EdU-positive nuclei. Scale bars: 100 μm. (D) Wound healing assays were used to investigate the migratory ability of A549 cells. (E) Transwell assays were used to investigate the changes in migratory abilities of A549 cells. (F) The effects of AK126698 on A549 cell apoptosis were determined by flow cytometric analysis. The experiments were all repeated at least three times. ^*P<0.05, ^**P<0.01.

Abbreviations: CCK-8, cell counting kit-8; EdU, 5-ethynyl-2′-deoxyuridine; lncRNA, long noncoding RNA; qRT-PCR, quantitative real-time polymerase chain reaction.