Table 3.
Oral Contraceptive Use and Risk of Steroid Prescription
| Never | Past | Current | P trend | ||
|---|---|---|---|---|---|
| Cases/person-months | 405/268,059 | 28/20,995 | 25/14,225 | ||
| Incident rate/100,000 person-months | 15.1 | 13.3 | 17.6 | ||
| Age-adjusted HR (95% CI) | 1.00 | 1.01 (0.69–1.49) | 1.18 (0.79–1.76) | ||
| MV-adjusted HR (95% CI)a | 1.00 | 0.98 (0.66–1.44) | 1.09 (0.73–1.64) | ||
| Cumulative duration of use, y | |||||
|
|
|||||
| 0 | ≤1 | >1 and ≤3 | >3 | ||
|
|
|||||
| Cases/person-months | 405/268,059 | 19/12,497 | 22/13,470 | 12/9253 | |
| Incident rate/100,000 person-months | 15.1 | 17.1 | 16.3 | 13.0 | |
| Age-adjusted HR (95% CI) | 1.00 | 1.02 (0.64–1.61) | 1.18 (0.77–1.82) | 1.04 (0.58–1.86) | .58 |
| MV-adjusted HR (95% CI)a | 1.00 | 0.99 (0.63–1.58) | 1.11 (0.72–1.71) | 0.95 (0.53-1.71) | .88 |
| Cumulative DDD use | |||||
|
|
|||||
| 0 | ≤300 | >300 and ≤900 | >900 | ||
|
|
|||||
| Cases/person-months | 405/268,059 | 19/10,104 | 26/13,090 | 22/14,847 | |
| Incident rate/100,000 person-months | 15.1 | 18.8 | 19.9 | 14.8 | |
| Age-adjusted HR (95% CI) | 1.00 | 1.28 (0.81–2.03) | 1.43 (0.96–2.13) | 1.18 (0.77–1.83) | .09 |
| MV-adjusted HR (95% CI)a | 1.00 | 1.27 (0.80–2.02) | 1.33 (0.89–1.99) | 1.11 (0.72–1.72) | .20 |
a
Adjusted for age (years), number of encounters, duration of disease (years), and county.