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. 2016 Jun 15;57(7):3145–3151. doi: 10.1167/iovs.16-19607

Figure 1.

Figure 1

Deletion of p110α significantly reduced sizes of eyes and lenses. (A). There were no significant differences in overall body sizes among wild-type, p110α KO, p110β KO, and p110α/p110β double-KO animals up to 24 weeks of age (P > 0.05). (B) In contrast, eye mass was reduced 18% at 1 week and 22% at 12 weeks in p110α KO animals compared to that in wild-type littermates (P < 0.05). (C) Plotting lens volume versus age for all knockouts showed that p110α KO lenses were 27% smaller at 1 week and 26% smaller at 12 weeks than those of wild-type animals (P < 0.05). p110β KO lenses were similar to those of wild-type mice at all ages examined, and the size of p110α/p110β double-KO lenses resembled those of the p110α single-KOs. Data are mean ± SD; n = 11–46 animals of each genotype at each time point.