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PI3K knockout lenses lacked histological abnormalities. (A) On P7, sagittal sections through the central region of wild-type lenses appeared normal (200×). (B) p110α KO and (C) p110α/p110β double-KO lenses also lacked any structural anomalies, except they were smaller than those of wild-type mice. (D–F) Higher magnification (400×) views showed normal differentiation of lens fibers from equatorial epithelial cells in all three genotypes of lenses.
