Figure 5.

Distribution of proliferating cells is altered in p110α KO lenses. (A–F) Wild-type lenses displayed a characteristic pattern of EdU labeling between E14 and P2, with the greatest proliferation observed in the circumferential germinative zone near the lens equator. (G–J) Between E14 and E17, p110α KO lenses had a pattern of proliferation similar to that of wild-type littermates. (K) On P0, EdU staining in the circumferential germinative zone was greatly reduced in p110α KO mice. (L) On P2, the characteristic pattern of EdU labeling was restored in p110α KO lenses.