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. 2016 Jun 17;57(7):3257–3267. doi: 10.1167/iovs.15-18993

Figure 3.

Figure 3

Large changes in expression of early stress response genes after light exposure. mRNA levels of select genes ([A1–A3] upregulated, Lcn2, Edn2, Socs3; [B1–B3] downregulated, Rho, Rpe65, Rdh12) were analyzed by qRT-PCR in whole eyes of 4-week-old Abca4−/−Rdh8−/− mice collected 3 and 24 hours, and 7 days after light exposure. Results were consistent with RNA-seq data. Fold changes in expression are compared to no light exposed Abca4−/−Rdh8−/− mice. The expression of each gene was normalized to the housekeeping gene Gapdh. Error bars: SD of the means (n = 3). *P < 0.05, light versus no light exposed.