Figure 1.

Differentially methylated CpG sites in PCa versus adjacent benign tissue. A, Manhattan plot of DNA methylation. The horizontal axis shows the chromosomes. Between each chromosome, a 10,000 bp ‘gap’ is shown to aid visualization. The dashed line represents the P-value that corresponds to an FDR Q-value threshold for statistical significance of 0.001. In total, 1,946 hypermethylated and 94 hypomethylated CpGs reached statistical significance. B, the frequencies of all evaluated CpG sites and those that were significantly hyper- and hypo-methylated by gene region. Gene regions are based on Illumina HM450 methylation data. Statistically significant differences are highlighted: P-value <0.05 (*); <0.01 (**); <0.001 (***).