Table 3. Experimentally Determined Thermodynamic Solubility in Surfactants and Cosolvents at 37 °Ca.
| compound | Cremophor EL (mg/g) | PS80 (mg/g) | Carbitol (mg/g) | PEG400 (mg/g) |
|---|---|---|---|---|
| acitretin | 2.85 ± 0.14 | 3.09 ± 0.03 | 3.52 ± 0.20 | 1.07 ± 0.01 |
| albendazole | 2.75 ± 0.14 | 2.09 ± 0.12 | 5.99 ± 0.19 | ≥5.75 |
| bezafibrate | 37.9 ± 5.23 | 31.8 ± 1.20 | 43.0 ± 1.83 | 36.0 ± 1.71 |
| candesartan | 11.3 ± 0.67 | 5.04 ± 0.94 | 20.5 ± 1.26 | 12.9 ± 1.33 |
| candesartan c | 26.4 ± 1.46 | 26.3 ± 0.54 | 77.0 ± 2.04 | 25.9 ± 0.86 |
| carbamazepine | 34.5 ± 1.06 | 34.6 ± 1.45 | 82.9 ± 1.80 | 73.9 ± 4.71 |
| cinnarizine | 22.7 ± 1.83 | 29.3 ± 0.92 | 54.3 ± 2.76 | 19.5 ± 0.89 |
| clofazimine | 15.9 ± 0.83 | 15.6 ± 1.04 | 22.8 ± 0.54 | 13.2 ± 0.61 |
| clotrimazole | 44.1 ± 3.01 | 51.1 ± 3.18 | 135.0 ± 3.57 | 74.5 ± 5.92 |
| danazol | 29.8 ± 0.50 | 30.1 ± 4.37 | 83.2 ± 1.97 | 35.8 ± 2.04 |
| diflunisal | 157.9 ± 6.54 | 119.7 ± 12.4 | 286.3 ± 13.4 | 169.2 ± 27.3 |
| dipyridamole | 9.57 ± 0.29 | 8.31 ± 0.37 | 43.1 ± 2.40 | 16.9 ± 0.80 |
| disulfiram | 88.8 ± 3.66 | 55.7 ± 3.32 | 162.6 ± 8.46 | 69.6 ± 3.26 |
| ethinylestradiol | 163.9 ± 10.1 | ≥99.4 | 247.1 ± 8.93 | ≥163 |
| felodipine | 125.1 ± 6.23 | 45.2 ± 4.36 | 217.2 ± 16.0 | 43.9 ± 6.25 |
| fenbendazole | 2.07 ± 0.09 | 1.90 ± 0.05 | 4.13 ± 0.28 | 2.83 ± 0.07 |
| fenofibrate | 101.3 ± 5.76 | 102.3 ± 3.15 | 201.7 ± 11.1 | 65.1 ± 4.94 |
| fenofibric acid | 58.4 ± 2.59 | 57.1 ± 2.49 | 92.8 ± 4.81 | 54.8 ± 2.69 |
| glibenclamide | 11.2 ± 1.01 | 10.5 ± 0.22 | 21.1 ± 0.46 | 8.25 ± 0.32 |
| griseofulvin | 9.70 ± 0.36 | 8.13 ± 0.27 | 18.9 ± 0.99 | 13.5 ± 0.60 |
| halofantrine | 27.9 ± 0.79 | 25.0 ± 1.60 | 79.3 ± 7.90 | 5.73 ± 0.38 |
| haloperidol | 11.3 ± 0.82 | 7.06 ± 0.64 | 27.2 ± 1.82 | 12.3 ± 0.92 |
| indomethacin | 71.6 ± 4.57 | 116.1 ± 8.33 | 187.4 ± 7.08 | 134.6 ± 11.3 |
| itraconazole | 1.92 ± 0.29 | 1.42 ± 0.19 | 6.30 ± 0.55 | 2.47 ± 0.08 |
| mefenamic acid | 30.7 ± 0.89 | 26.2 ± 0.65 | 43.6 ± 1.52 | 25.1 ± 0.86 |
| naproxen | 119.9 ± 2.97 | 106.6 ± 4.31 | 183.0 ± 4.92 | 132 ± 2.87 |
| niclosamide | 44.1 ± 1.75 | 30.2 ± 1.77 | 49.6 ± 2.62 | 61.7 ± 1.72 |
| noscapine | 12.3 ± 0.25 | 14.3 ± 0.91 | 25.6 ± 1.00 | 19.4 ± 0.94 |
| perphenazine | 71.7 ± 3.04 | 76.6 ± 4.35 | 232.6 ± 13.4 | 98.4 ± 4.32 |
| praziquantel | 45.4 ± 3.51 | 19.2 ± 1.20 | 116.9 ± 14.8 | 28.0 ± 1.08 |
| progesterone | 41.1 ± 1.27 | 28.3 ± 2.19 | 67.02 ± 1.36 | 17.1 ± 0.71 |
| saquinavir | ≥45.9 | 48.9 ± 2.15 | ≥317 | ≥300 |
| sulfasalazine | 13.1 ± 1.02 | 11.4 ± 0.63 | 16.4 ± 0.72 | 11.8 ± 0.58 |
| tolfenamic acid | 70.6 ± 3.87 | 57.3 ± 7.05 | 85.5 ± 4.29 | 46.8 ± 7.00 |
| toltrazuril | 19.7 ± 3.11 | 11.1 ± 1.29 | 50.2 ± 2.47 | 18.3 ± 2.27 |
| min | 1.92 | 1.42 | 3.52 | 1.07 |
| max | 163.9 | 119.7 | ≥317 | ≥300 |
a
Abbreviations: Candesartan cilexetil (candesartan c).