Table 5.
TB diagnostic criteria by NIH classification of intrathoracic TB disease for those with NIH signs or symptoms suggestive of TB
| TB disease characteristic | NIH classification
|
Total (N=166) | P-Value1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Confirmed TB (n=21) |
Probable TB (n=92) |
Possible TB (n=45) |
Sub-total TB (N=158) |
TB unlikely (n=6) |
Alternative Diagnosis (n=2) |
Sub-total Not TB (N=8) |
|||
|
| |||||||||
| Culture positive | 21 (100%) | 0 (0%) | 0 (0%) | 21 (13%) | 0 (0%) | 0 (0%) | 0 (0%) | 21 (13%) | 0.60 |
| Persistent cough (>2 weeks) | 0 (0%) | 0 (0%) | 2 (4%) | 2 (1%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (1%) | >0.999 |
| Persistent fever (>1 week) | 0 (0%) | 0 (0%) | 2 (4%) | 2 (1%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (1%) | >0.999 |
| Lethargy | 0 (0%) | 1 (1%) | 0 (0%) | 1 (1%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (1%) | >0.999 |
| Any weight-related symptom2 | 21 (100%) | 92 (100%) | 43 (96%) | 156 (99%) | 6 (100%) | 2 (100%) | 8 (100%) | 164 (99%) | >0.999 |
| Weight loss >5% | 3 (14%) | 4 (4%) | 5 (11%) | 12 (8%) | 0 (0%) | 0 (0%) | 0 (0%) | 12 (7%) | >0.999 |
| Met at least one definition of FTT3 | 21 (100%) | 92 (100%) | 43 (96%) | 156 (99%) | 6 (100%) | 2 (100%) | 8 (100%) | 164 (99%) | >0.999 |
| Crossed at least 1 weight for age or weight for height major percentile | 19 (90%) | 76 (83%) | 34 (76%) | 129 (82%) | 5 (83%) | 2 (100%) | 7 (88%) | 136 (82%) | >0.999 |
| Weight for age or weight for height Z-score < −2 | 6 (29%) | 31 (34%) | 21 (47%) | 58 (37%) | 3 (50%) | 0 (0%) | 3 (38%) | 61 (37%) | >0.999 |
| FTT diagnosis recorded on comprehensive diagnosis form | 8 (38%) | 16 (17%) | 10 (22%) | 34 (22%) | 4 (67%) | 0 (0%) | 4 (50%) | 38 (23%) | 0.082 |
| CXR consistent with TB | 14 (67%) | 92 (100%) | 32 (71%) | 138 (87%) | 0 (0%) | 0 (0%) | 0 (0%) | 138 (83%) | <0.001 |
| Soft tissue density (STD) suggestive of lymphadenopathy | 10 (48%) | 76 (83%) | 21 (47%) | 107 (68%) | 0 (0%) | 0 (0%) | 0 (0%) | 107 (64%) | <0.001 |
| Both STD suggestive of lymphadenopathy and air space opacification | 6 (29%) | 38 (41%) | 18 (40%) | 62 (39%) | 0 (0%) | 0 (0%) | 0 (0%) | 62 (37%) | 0.026 |
| TB exposure in preceding 24 months | 5 (24%) | 25 (27%) | 6 (13%) | 36 (23%) | 0 (0%) | 0 (0%) | 0 (0%) | 36 (22%) | 0.20 |
| TST positive | 9 (43%) | 75 (82%) | 9 (20%) | 93 (59%) | 0 (0%) | 0 (0%) | 0 (0%) | 93 (56%) | 0.001 |
| Response to anti-TB therapy | 1 (5%) | 20 (22%) | 2 (4%) | 23 (15%) | 0 (0%) | 0 (0%) | 0 (0%) | 23 (14%) | 0.60 |
| AFB positive result | 10 (48%) | 8 (9%) | 8 (18%) | 26 (16%) | 3 (50%) | 0 (0%) | 3 (38%) | 29 (17%) | 0.145 |
1
Fisher’s Exact Test comparing TB vs not TB groups
2
Weight loss >5% or met at least one definition of FTT
3
Crossed at least 1 weight for age or weight for height major percentile, weight for age or weight for height Z-score <−2, or FTT diagnosis recorded on comprehensive diagnosis form