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. 2016 May 6;2(5):e1501372. doi: 10.1126/sciadv.1501372

Fig. 1. Biosynthesis of octopamine is up-regulated during starvation.

Fig. 1

(A) Expression of Ptbh-1::gfp was up-regulated in starved worms relative to well-fed worms (in the presence of E. coli OP50). The right panel shows quantification of GFP levels. (B) The mRNA levels of tbh-1 were determined by qRT-PCR. (C) The levels of octopamine in starved worms were higher than those in well-fed worms. Results are means ± SD of three experiments. *P < 0.05 versus well-fed worms. (D) Survival rate of tbh-1(n3247) worms was lower than that of wild-type (WT) worms after 3 days of starvation. Exogenous octopamine (OA; 1 mM) markedly restored the survival of tbh-1(n3247) worms. Results are means ± SD of three experiments. aP < 0.05, tbh-1(n3247) versus WT worms; bP < 0.05, tbh-1 + octopamine versus tbh-1.