Fig. 6. Expansion of polyguanine repeats occurs at a high rate and is RAD52-dependent.

(A) Mutation rates of G₀ and G₁₄-ORF strains compared to their respective rev1 deletion mutants. (B) Mutation rates of G₀, G₁₄-repeat, and G₁₄-ORF strains, shown relative to the G₀ mutation rate. (C and D) In each panel, the mutation rates of deletion mutants are shown relative to their respective nondeletion progenitor, either G₀ (C), G₁₄-ORF (C), or G₁₄-repeat (D). Significant differences calculated using t tests are indicated by asterisks: *P < 0.05 and **P < 0.005. Error bars represent 95% confidence intervals.