Table 2.
Carboxymethyl lysine (CML) levels at baseline in the cohort random sample. Atherosclerosis Risk in Communities Study.
| n | Weighted proportion | Mean CML* (95%CI), ng/mL | p value† | |
|---|---|---|---|---|
| Sex | ||||
| Women | 402 | 64.9% | 241.3 (233.1 – 249.4) | <0.001 |
| Men | 206 | 35.1% | 269.6 (257.1 – 282.1) | |
| Ethnicity | ||||
| African-American | 295 | 20.2% | 261.3 (249.8 – 272.9) | 0.09 |
| White | 313 | 79.8% | 248.7 (241.1 – 256.2) | |
| Age | ||||
| 45–54 years | 409 | 64.9% | 237.9 (218.1 – 257.7) | 0.18 |
| 55–64 years | 199 | 35.1% | 247.7 (240.1 – 255.4) | |
| GFR (1st quartile) ‡ | ||||
| Yes | 122 | 24.7% | 254.9 (241.2 – 268.6) | 0.54 |
| No | 486 | 75.3% | 250.0 (243.0 – 257.0) | |
| Smoking | ||||
| Current | 133 | 19.7% | 250.3 (237.8 – 262.8) | 0.91 |
| Former | 183 | 31,9% | 253.6 (240.7 – 266.4) | |
| Never | 292 | 48.4% | 250.0 (241.0 – 259.0) | |
| Inflammation score | ||||
| High | 263 | 37.3% | 253.3 (245.2 – 261.5) | 0.41 |
| Low | 345 | 62.7% | 259.1 (239.2 – 279.0) | |
| Body mass index | ||||
| Normal | 194 | 39.1% | 256.3 (245.6 – 267.0) | 0.42 |
| Overweight | 245 | 41.7% | 246.7 (237.6 – 255.8) | |
| Obese | 169 | 19.2% | 250.6 (235.1 – 266.1) | |
*
Adjusted for age, sex, race/centre, parental history of diabetes, BMI, BMI2, waist-to-hip ratio, NEFA, oxidized LDL-cholesterol, glomerular filtration rate (CKD-EPI), smoking (cigarettes/day*years), inflammation score, adiponectin, leptin, ln-insulin, and glucose (baseline values)
†
Weighted ANCOVA
‡
Glomerular filtration rate < 61.8 mL/min per 1.73 m2