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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Pediatr Gastroenterol Nutr. 2016 Aug;63(2):200–209. doi: 10.1097/MPG.0000000000001100

Figure 3. TGFβ enhances fibroblast contractility in a soft matrix.

Figure 3

Fibroblasts were embedded into collagen gel matrices and allowed to contract for 4 days. (A) Images of representative gel matrices from Day 0 and Day 4 are shown in panel. (B) Average percent contraction of gels after 4 days of contraction with and without TGFβ in all four patient phenotypes showed significant increases in contraction with TGFβ stimulation of pediatric normal (p=0.01), pediatric EoE (p=0.0015), and adult EoE (p=0.0003) but not adult normal fibroblasts. n=5,7,11, and 4, respectively. *p<0.05 compared to TGFβ(-).