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. Author manuscript; available in PMC: 2017 Jun 30.
Published in final edited form as: J Neurochem. 2016 Jan 17;136(6):1246–1258. doi: 10.1111/jnc.13518

Figure 5.

Figure 5

Recovery of PS1C does not necessarily restore the γ-secretase activity toward APP in NCT−/− cells. Knockout cells were cultured in the presence or absence of MG132. Up panel, immunoblot probed with anti-PS1C that recognizes both regular and caspase produced PS1C; bottom panel, immunoblot probed with C15. Lane 12 is the sample prepared from wt-7 cells treated with compound E used as standards of CTFβ-myc and CTFα-myc.