Fig 4.

A, Trace indicates changes in tracheal pressure (top) and action potential firing (bottom) of Aδ- and C-fibers in response to GSK1016790A (10 μg/mL). B and C, Total impulses were significantly increased after application of citric acid (CA; 0.3 mol/L) and GSK1016790A (10 μg/mL) in Aδ-fibers (Fig 4, B), but only capsaicin (Caps; 100 μmol/L) and citric acid (0.3 mol/L) significantly increased firing in C-fibers (Fig 4, C). D and E, Hypo-osmotic solution (−80 mOsm) significantly increased total impulses in Aδ-fibers but had no effect on C-fibers (Fig 4, D and E, respectively). Data are presented as means ± SEMs of 3 or 4 observations. Veh, Vehicle. *Statistical significance (P < .05), paired t test comparing responses before and after aerosol administration of agonist.