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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Immunol. 2016 May 20;197(1):288–295. doi: 10.4049/jimmunol.1501946

FIGURE 4.

FIGURE 4

GEMs association dysfunctional GP Ibα mitigates atheroma formation in ApoE deficient animals fed HCD. All samples were collected from mice on HCD for 16 weeks starting at the age of 6 months. A. Representative oil red staining of the aortas of mice (n=12) fed either HCD or normal diet (ND). B. Quantification of atherosclerotic lesions in whole aortas was done using Image J software. Mouse aortas were digested with a mixture of enzymes and the CD45+ (C) and CD11c+ (D) leukocytes were counted in aortas of 16 weeks HCD-fed animals (n=8 of each group, age and gender matched). E. The CD11c+ cells are reduced to a greater extent than other CD45+ cell types in mutant and GP Ibα deficient mice when compared to the wild type animals.