Table 2. Comparison of inflammatory markers between T allele carriers and CC genotype in total study population and separately in obese and non-obese patients.
| Variable | IL-18, pg/mL | PTX3, ng/mL | hs-CRP, mg/L |
|---|---|---|---|
| TT+TC (n=120) | 248.41±32.33 | 2.68±0.46 | 1.92±1.34 |
| CC (n=60) | 251.10±27.50 | 2.51±0.45 | 2.83±1.65 |
| Mean difference (95% CI) | 2.33 (-7.23 to 11.90) | -0.16 (-0.30 to -0.02) | 0.91 (0.46 to 1.36) |
| P valuea | 0.63 | 0.02 | <0.001 |
| P valueb | 0.54 | 0.01 | 0.001 |
| Obese (n=90) | |||
| TT+TC | 254.14±35.64 | 2.59±0.38 | 2.28±1.22 |
| CC | 256.89±28.49 | 2.44±0.51 | 3.04±1.61 |
| Mean difference (95% CI) | 1.44 (-13.27 to 16.15) | -0.15 (-0.34 to 0.03) | 0.77 (0.17 to 1.37) |
| P valuea | 0.84 | 0.02 | 0.014 |
| P valuec | 0.91 | 0.03 | 0.008 |
| Non-obese (n=90) | |||
| TT+TC | 242.37±27.69 | 2.76±0.52 | 1.55±1.37 |
| CC | 245.31±25.79 | 2.59±0.37 | 2.59±1.69 |
| Mean difference (95% CI) | 2.94 (-9.08 to 14.98) | -0.17 (-0.38 to 0.04) | 1.03 (0.37 to 1.69) |
| P valuea | 0.62 | 0.04 | 0.002 |
| P valuec | 0.88 | 0.04 | 0.01 |
Values are presented as mean±standard deviation.
IL-18, interleukin 18; PTX3, pentraxin 3; hs-CRP, high-sensitivity C-reactive protein; CI, confidence interval.
aUsing the independent t-test, bAdjusted for body mass index, age, sex, and monounsaturated fatty acid (MUFA) using the analysis of covariance (ANCOVA), cAdjusted for waist circumference, age, sex, and MUFA using the ANCOVA.