Table 2.
Other agents that target Aβ metabolism
| Targets of the agents | Details | Agents under investigation | Status | Ref. |
|---|---|---|---|---|
| Apolipoprotein (ApoE) and Aβ clearance | Nuclear receptor modulator and ApoE activator | Bexarotene | – | 74 |
| Enzymes that degrade Aβ (NEP, IDE, ECE, ACE) | Increases NEP activity |
Valproic acid Oestrogen Green tea |
– | 75 |
| Aβ transport | Antibodies against LRP | – | – | 76 |
| Intraneuronal Aβ transport | Cerebrolysin | – | 77 | |
| Aβ signaling | Blocks Fyn kinase or cellular prion proteins | Saracatinib | (II) | 76 |
| Intravenous immunoglobulin | Clearance of Aβ | – | – | 78 |
| Medications that influence Aβ blood–brain barrier transport | Inhibition of RAGE | – | – | 64 |
| Activation of LRP‐1 |