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. 2016 May 5;594(13):3745–3774. doi: 10.1113/JP272231

Figure 13. Recovery of transmission at PV+BC synapses can be a refractory mechanism of SWR generation .

Figure 13

A, plotting the interaction between the amplitude of spontaneous SWRs and the time subsequent to the previous SWR shows that SWR amplitude recovers with a half‐time similar to the recovery half‐time of transmission between PV+BCs and PCs (B). The recovery of transmission was calculated from two sets of RIP protocols (four APs at 160 Hz with an interstimulus interval between 50 and 1200 ms) and the recovery ratio of evoked IPSCs was calculated by dividing the amplitude of the first IPSC of the second train by the amplitude of the first IPSC of the first train, and plotted against the interstimulus interval. C, top: optogenetic stimulation of PV+ cell population evoked SWRs (blue bars, 10 ms illumination) between spontaneous SWRs (asterisks). The amplitude of the evoked SWR depended on the time period between the spontaneous SWR (asterisk) and stimulation onset. Bottom: plotting the interaction between the amplitude of evoked SWR and the time subsequent to the previous spontaneous SWR revealed that the amplitude of light‐evoked SWRs depends on the gap subsequent to the previous spontaneous SWR. Note the absence of SWRs (full refractoriness) in the 200 ms window following the spontaneous SWR.