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. 2016 Jun 9;594(13):3683–3703. doi: 10.1113/JP271929

Figure 8. Modelling shows that convergence of EPSC and IPSC kinetics is required for maturation of IID functions .

Figure 8

The relative time‐course of excitatory (green) and inhibitory (red) synaptic inputs to the LSO is shown for the three conditions: Hearing onset, Adult and following acoustic trauma. In the lower graphs the LSO model output is shown normalized to the input firing rate (corresponding to sound intensity) plotted against the IID across a range of firing frequencies from 100 to 300 Hz (colour coded as indicated on the right: 100 Hz, blue; 300 Hz, orange). A, at Hearing onset, inhibitory synaptic currents in the LSO have slow kinetics and large amplitudes. This makes inhibition more effective than excitation and shifts IID functions to the left for higher input frequencies. B, balanced amplitudes and kinetics of EPSCs and IPSCs result in a normal distribution of IID functions in the mature LSO. C, AT causes a deceleration of the excitatory synaptic currents, increasing the effectiveness of excitation and leading to a rightward shift of the IID functions.