Table 3.

Association between ceramides and cardiovascular death in BECAC^a

	Univariate model		Multivariableb model 1b		Multivariablec model 2c
	Hazard ratiod (95% CI)	P-value	Hazard ratiod (95% CI)	P-value	Hazard ratiod (95% CI)	P-value
Cer(d18:1/16:0)/Cer(d18:1/24:0)e	1.77 (1.46–2.16)	<0.001	1.79 (1.45–2.20)	<0.001	1.52 (1.21–1.92)	<0.001
Cer(d18:1/18:0)/Cer(d18:1/24:0)e	1.63 (1.31–2.04)	<0.001	1.58 (1.25–2.00)	<0.001	1.29 (1.01–1.65)	0.039
Cer(d18:1/24:1)/Cer(d18:1/24:0)e	1.61 (1.30–1.98)	<0.001	1.58 (1.27–1.97)	<0.001	1.31 (1.03–1.66)	0.028
Cer(d18:1/16:0)e	1.44 (1.17–1.77)	<0.001	2.09 (1.61–2.73)	<0.001	1.75 (1.30–2.35)	<0.001
Cer(d18:1/18:0)e	1.33 (1.07–1.65)	0.011	1.54 (1.19–2.01)	0.001	1.27 (0.98–1.66)	0.076
Cer(d18:1/24:0)e	0.83 (0.67–1.02)	0.081	0.82 (0.62–1.10)	0.182	0.91 (0.69–1.21)	0.510
Cer(d18:1/24:1)e	1.39 (1.13–1.72)	0.002	1.74 (1.34–2.25)	<0.001	1.38 (1.04–1.82)	0.023

Cer denotes ceramide.

^aCV death denotes death from MI, stroke, and heart failure.

^bThe model was adjusted for TC, TG, HDL-C, and LDL-C.

^cThe model was adjusted as for model 1 with additional adjustment for the following Marschner score variables: age, gender, smoking status, previous acute MI, diabetes, hypertension, and prior stroke.

^dHazard ratios are for 1 SD increase.

^eNatural logarithm of the ceramides and ceramide ratio.