Figure 1.

Model depicting genomic and epigenetic events during cancer progression. Numerous genetic events, like gene amplifications, deletions, gene fusions, and mutations of oncogenes and tumor suppressor genes, are common in cancer. In addition, many histone modifiers also show aberrant regulation in cancer. These changes modulate gene expression during cancer progression. DNA methylation and demethylation are also common occurrence in cancer and lead to altered regulation of gene expression. Many of these genomic and epigenetic regulators are effective therapeutic targets in cancer. EGFR, epidermal growth factor receptor.