Table 1.

Common Histone-Modifying Enzymes Amplified/Overexpressed/Mutated in Cancer

Gene	Cancer type	Alteration	References
EZH2	Prostate, breast, bladder, ovarian, lung, liver, brain, kidney, gastric, esophageal, and pancreatic cancer and melanoma	Amplified/overexpressed	36
MLL4	Breast	Amplification	37
SETDB1	Melanoma, lung, prostate	Overexpressed/amplification	35, 38, 39
EHMT1	Esophageal	Overexpressed	40
EHMT2	Bladder, breast, cervical, lung, and others	Overexpressed	41
KDM1A	Prostate, bladder	Overexpression	42
KDM6A	Acute myelogenous leukemia, bladder	Down-regulation	17
PCAF	Epithelial	Missense mutation	43
P300	Gastric, colon, breast	Biallelic and stop codon mutations	44
HDAC1	Gastric, prostate	Overexpression	45, 46
AURKB	Colorectal	Overexpression	47
BUB1	Gastric	Overexpression	48
RING2 and UBCH6	Role in cancer yet to be confirmed		49