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. 2016 Jul;186(7):1837–1846. doi: 10.1016/j.ajpath.2016.03.008

Figure 8.

Figure 8

Small-bowel resection (SBR) decreases TP53 in human infants. Representative images of TP53 staining from control and resected infant (<1 year) human SB. A: Normal ileum [control (ctl)]. B: Ileostomy take down with history of necrotizing enterocolitis (SBR). C: Ostomy repair after spontaneous perforation (SBR). Arrowheads identify TP53-positive intestinal epithelial cell (IEC) (A–C). Boxed areas are shown in higher magnification on the right (A–C). D: Quantification of the percentage of TP53-positive cells in the crypt base (positions 1 to 5 in the hemicrypt), middle crypt (transit amplifying zone, positions 6 to 15), and upper crypt (position ≥16) in control (black bars) and post-resection (gray bars) ileum. Data are shown as the means ± SEM (D). n = 3 (D, control); n = 6 (D, post-resection). ∗P < 0.05 versus control. Scale bar = 100 μm (A–C). Original magnification: ×9.2 (A, boxed area); ×5.0 (B, boxed area); ×4.0 (C, boxed area).