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. 2016 Jul;186(7):1874–1889. doi: 10.1016/j.ajpath.2016.03.010

Figure 1.

Figure 1

Expression of Delta-like ligand 4 (DLL4) in sinusoidal cells. A: Immunohistochemical staining shows that Jagged (JAG)1, DLL4, and NOTCH1 localize in sinusoidal cells in cirrhotic patients with hepatitis B virus infection. B–D: Costaining for DLL4 and α-smooth muscle actin (α-SMA)/CD68/CD16 was performed in four cirrhotic patients with high levels of DLL4 positivity in sinusoids. Representative patients show costaining for DLL4 and α-SMA (B), DLL4 and CD68 (C), and DLL4 and CD16 (D). Scale bars: 20 μm (A); 50 μm (B–D). Con, control; HBV, hepatitis B virus; Pat., patient.