Table 1.
Pathway analysis of top 61 protein-protein interaction (PPI) genes.
| Pathway Name(ID) | Annotated Genes Quantity | Corrected P-value | Annotated Genes |
|---|---|---|---|
| Signal Transduction(REACT:111102) | 23 | 1.67 × 10−13 | CASP3|CDKN1A|CDKN1B|CHUK|COL3A1|COL4A1|E2F3|E2F5|EDN1|FRS2|GRB2|IGF1R|IRS2|NGF|NRAS|PRKAR1A|PRKCE|PTEN|SDC2|THBS1|TSC1|YAP1|YWHAB |
| Cell cycle(KEGG:04110) | 10 | 1.59 × 10−12 | CCNE2|CDC25A|CDKN1A|CDKN1B|E2F3|E2F5|ESPL1|SMC1A|YWHAB|YWHAG |
| Prostate cancer(KEGG:05215) | 9 | 3.82 × 10−12 | CCNE2|CDKN1A|CDKN1B|CHUK|E2F3|GRB2|IGF1R|NRAS|PTEN |
| Pathways in cancer(KEGG:05200) | 12 | 2.70 × 10−11 | APPL1|CASP3|CCNE2|CDKN1A|CDKN1B|CHUK|COL4A1|E2F3|GRB2|IGF1R|NRAS|PTEN |
| Cell Cycle(REACT:115566) | 13 | 2.82 × 10−10 | CCNE2|CDC25A|CDKN1A|CDKN1B|DYRK1A|E2F3|E2F5|ESPL1|NUP98|RANBP2|RRM2|SMC1A|YWHAG |
| Immune System(REACT:6900) | 17 | 3.00 × 10−10 | CDKN1A|CDKN1B|CHUK|FRS2|GRB2|IRS2|MAP3K1|NRAS|NUP98|PAK1|PRKAR1A|PRKCE|PTEN|RANBP2|TNFAIP3|WASL|YWHAB |
| Disease(REACT:116125) | 16 | 4.79 × 10−10 | CDKN1A|CDKN1B|CHUK|E2F5|FRS2|GRB2|IRS2|NRAS|NUP98|POLR2D|PRKAR1A|PRKCE|PTEN|RANBP2|SDC2|YWHAB |
| p53 signaling pathway(KEGG:04115) | 7 | 2.67 × 10−19 | CASP3|CCNE2|CDKN1A|MDM4|PTEN|RRM2|THBS1 |
| Neurotrophin signaling pathway(KEGG:04722) | 8 | 5.35 × 10−19 | FRS2|GRB2|IRS2|MAP3K1|NGF|NRAS|YWHAB|YWHAG |
| Oocyte meiosis(KEGG:04114) | 7 | 1.02 × 10−7 | CCNE2|CPEB1|ESPL1|IGF1R|SMC1A|YWHAB|YWHAG |
| Glioma(KEGG:05214) | 6 | 1.40 × 10−7 | CDKN1A|E2F3|GRB2|IGF1R|NRAS|PTEN |
| Focal adhesion(KEGG:04510) | 8 | 2.53 × 10−7 | COL1A1|COL3A1|COL4A1|GRB2|IGF1R|PAK1|PTEN|THBS1 |
| Chronic myeloid leukemia(KEGG:05220) | 6 | 3.38 × 10−7 | CDKN1A|CDKN1B|CHUK|E2F3|GRB2|NRAS |
| Small cell lung cancer(KEGG:05222) | 6 | 8.35 × 10−7 | CCNE2|CDKN1B|CHUK|COL4A1|E2F3|PTEN |
| Melanoma(KEGG:05218) | 5 | 1.47 × 10−5 | CDKN1A|E2F3|IGF1R|NRAS|PTEN |
| Extracellular matrix organization(REACT:118779) | 7 | 3.25 × 10−5 | CASP3|COL14A1|COL1A1|COL3A1|COL4A1|SDC2|THBS1 |
| Developmental Biology(REACT:111045) | 8 | 3.98 × 10−5 | COL3A1|COL4A1|GRB2|MED8|NRAS|PAK1|WASL|YWHAB |
| ECM-receptor interaction(KEGG:04512) | 5 | 4.34 × 10−5 | COL1A1|COL3A1|COL4A1|SDC2|THBS1 |
| MAPK signaling pathway(KEGG:04010) | 7 | 4.94 × 10−5 | CASP3|CHUK|GRB2|MAP3K1|NGF|NRAS|PAK1 |
| ErbB signaling pathway(KEGG:04012) | 5 | 5.14 × 10−5 | CDKN1A|CDKN1B|GRB2|NRAS|PAK1 |
| Bladder cancer(KEGG:05219) | 4 | 8.68 × 10−5 | CDKN1A|E2F3|NRAS|THBS1 |
| Cellular responses to stress(REACT:120956) | 6 | 2.53 × 10−4 | CBX4|CCNE2|CDKN1A|CDKN1B|E2F3|HMGA2 |
| Insulin signaling pathway(KEGG:04910) | 5 | 5.15 × 10−4 | GRB2|IRS2|NRAS|PRKAR1A|TSC1 |
| Protein digestion and absorption(KEGG:04974) | 4 | 0.00123 | COL14A1|COL1A1|COL3A1|COL4A1 |
| Apoptosis(KEGG:04210) | 4 | 0.00179 | CASP3|CHUK|NGF|PRKAR1A |
| Chemokine signaling pathway(KEGG:04062) | 5 | 0.00201 | CHUK|GRB2|NRAS|PAK1|WASL |
| Fc gamma R-mediated phagocytosis(KEGG:04666) | 4 | 0.00262 | CFL2|PAK1|PRKCE|WASL |
| Amoebiasis(KEGG:05146) | 4 | 0.0037 | CASP3|COL1A1|COL3A1|COL4A1 |
| T cell receptor signaling pathway(KEGG:04660) | 4 | 0.00412 | CHUK|GRB2|NRAS|PAK1 |
| Binding and Uptake of Ligands by Scavenger Receptors(REACT:160300) | 3 | 0.00499 | COL1A1|COL3A1|COL4A1 |
| Axon guidance(KEGG:04360) | 4 | 0.00865 | CFL2|EFNB2|NRAS|PAK1 |
| Extracellular matrix organization(REACT:195275) | 2 | 0.00935 | COL1A1|SDC2 |
| Hepatitis C(KEGG:05160) | 4 | 0.00998 | CDKN1A|CHUK|GRB2|NRAS |
| Measles(KEGG:05162) | 4 | 0.00998 | CCNE2|CDKN1B|CHUK|TNFAIP3 |
| Natural killer cell mediated cytotoxicity(KEGG:04650) | 4 | 0.01177 | CASP3|GRB2|NRAS|PAK1 |
| Endometrial cancer(KEGG:05213) | 3 | 0.01232 | GRB2|NRAS|PTEN |
| Non-small cell lung cancer(KEGG:05223) | 3 | 0.01232 | E2F3|GRB2|NRAS |
| Acute myeloid leukemia(KEGG:05221) | 3 | 0.01448 | CHUK|GRB2|NRAS |
| Apoptosis(REACT:578) | 4 | 0.01603 | APPL1|CASP3|YWHAB|YWHAG |
| Hemostasis(REACT:604) | 6 | 0.01944 | COL1A1|GRB2|NRAS|PRKAR1A|PRKCE|THBS1 |
| Epithelial cell signaling in Helicobacter pylori infection(KEGG:05120) | 3 | 0.02448 | CASP3|CHUK|PAK1 |
| Gene Expression(REACT:71) | 8 | 0.02501 | E2F5|IGF2BP1|MED8|NR3C1|POLR2D|SMC1A|YAP1|YWHAB |
| Renal cell carcinoma(KEGG:05211) | 3 | 0.02783 | GRB2|NRAS|PAK1 |
| B cell receptor signaling pathway(KEGG:04662) | 3 | 0.03815 | CHUK|GRB2|NRAS |
| Fc epsilon RI signaling pathway(KEGG:04664) | 3 | 0.04732 | GRB2|NRAS|PRKCE |