Table 2.
Literature survey of initial endometrial carcinoma-related genes.
| Gene Symbol | #of PPIs Neighbor | Relationship with Endometrial Carcinoma | Reference |
|---|---|---|---|
| PTEN | 25 | PTEN mutation is commonly found in endometrial carcinoma.PTEN expression is a diagnostic marker and poor prognostic factor. | [12,13,14,15] |
| CDKN1A(p21) | 15 | CDKN1A is a significantly mutated gene in endometrial carcinoma.Genetic polymorphisms and susceptibility to endometrial carcinoma | [16,17,18,19] |
| NRAS | 15 | NRAS is a significantly mutated gene in endometrial carcinoma. | [20] |
| CDC25A | 15 | Thought to be a oncogene in endometrial carcinoma | [21,22] |
| CDKN1B(p27Kip1) | 14 | CDKN1A has genetic polymorphisms and susceptibility to endometrial carcinomaCDKN1A has therapeutic potential for endometrial carcinoma | [19,23,24,25] |
| IGF1R | 14 | Potential therapy target of endometrioid adenocarcinoma | [26,27,28] |