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. 2016 Jul 1;6:28814. doi: 10.1038/srep28814

Figure 4. ROC analyses of IL34-FS, IL-34, other biomarkers, and fibrosis scores for diagnosis of each stage of patients with NAFLD.

Figure 4

Receiver-operating characteristic (ROC) curves of interleukin-34 based fibrosis score (IL34-FS), interleukin-34 (IL-34), macrophage-colony stimulating factor (M-CSF), soluble CD163 (sCD163), hyaluronic acid, type IV collagen 7s, aspartate transaminase (AST)-to-platelet ratio index (APRI), FIB-4 index, and NAFLD fibrosis score (NFS) as a diagnostic marker of liver fibrosis are shown for all stages. ROC curves for the diagnosis of each stage were as follows: (A–C) significant fibrosis (≥Stage 2), (D–F) advanced fibrosis (≥Stage 3), (G–I) liver cirrhosis (Stage 4). ROC curves were shown as follows: (A,D,G) IL34-FS, IL-34, M-CSF, and sCD163, (B,E,H) IL34-FS, macrophage inflammatory protein-3 alpha/C-C motif chemokine ligand 20 (MIP-3α/CCL20), hyaluronic acid, and type IV collagen 7s, (C,F,I) IL34-FS, APRI, FIB-4 index, and NFS.