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. 2016 Jul 1;6:28968. doi: 10.1038/srep28968

Figure 5. Knockdown of EGFR, AKT2, or CCND1 produces similar suppressive effects to that of miR-2861 overexpression in cervical cancer cells.

Figure 5

(A) Knockdown of EGFR, AKT2, or CCND1 suppresses cell proliferation of both SiHa and CaSki cells. CCK8 assay was performed to determine the growth of SiHa and CaSki cells treated with si-EGFR, si-AKT2, si-CCND1, or si-NS. (B,C) Knockdown of EGFR, AKT2, or CCND1 enhances cell apoptosis of SiHa and CaSki cells. Apoptosis assay was determined in SiHa and CaSki cells at 48 h after transfection of si-EGFR, si-AKT2, si-CCND1, or si-NS. Representative images are shown (C) and early apoptosis rate are indicated (B). **P < 0.01; ***P < 0.001.