Figure 4. Humoral immune responses in mice vaccinated with AV-1959R, AV-1980R, AV-1953R and mixture of AV-1959R and AV-1980R formulated with Advax^CpG adjuvant.

Concentrations of anti-Aβ (a) and anti-tau (b) antibodies were measured by ELISA in sera collected after the 3^rd immunization and calculated using calibration curves generated with 6E10 and 1C9 monoclonal antibodies, respectively. Lines represent mean values for n = 8/per group (*P < 0.05, **P < 0.01, ANOVA test).