Figure 5. Number of B cells producing anti-Aβ and anti-Tau antibodies in mice vaccinated with AV-1959R, AV-1980R, AV-1953R and mixture of AV-1959R and AV-1980R formulated with Advax^CpG adjuvant.

Detection of anti-Aβ (a) and anti-tau (b) antibody-secreting cells (ASC), visualized as spots, was done in splenocyte cultures obtained from experimental and control mice using ELISpot assay. Bars represent average ± SD (n = 8/per group, *P < 0.05, ANOVA test).