Skip to main content
. 2016 Jul 1;6:28811. doi: 10.1038/srep28811

Figure 7. TPβ expression in mice reduces labyrinthine formation and prevents trophoblast proliferation and differentiation as part of the IUGR phenotype.

Figure 7

(a) Representative images of H&E stained sections of placentae from pups born to Wt (n = 89) and TPβ-Tg (n = 48) dams at day 18.5 of gestation. (b) From the H&E stained sections, the size of the labyrinthine zone of placentae from pups (n = 9) born to Wt (□) dams and pups (n = 31) born to TPβ-Tg (Inline graphic) dams was elucidated using ImageJ software. Representative images (c) and quantification (d) of E-cadherin expression in the labyrinthine zone in placentae from pups (n = 47) born to Wt (□) dams and pups (n = 59) born to TPβ-Tg (Inline graphic) dams. Representative images (e) and quantification (f) of proliferation (PCNA staining) in the labyrinthine zone in placentae from pups (n = 53) born to Wt (□) dams and pups (n = 59) born to TPβ-Tg (Inline graphic) dams. All sections stained for E-cadherin and PCNA were imaged at 200x magnification, scale bar: 100 μm. The data are represented as mean ± SEM. Independent samples T-test, *P < 0.05, ****P < 0.001.