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Schematic signaling pathway for mSH3BGRL or hSH3BGRL mutant-mediated metastasis. mSH3BGRL-alike hSH3BGRL mutants or with modification activate the downstream FAK/Src complex and the further AKT and Erk signals via c-Src kinase, and selectively blocking hyperactive c-Src by specific antagonists, including siRNAs could effectively delay tumor cell metastasis.
