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. 2016 Jul 1;6:28899. doi: 10.1038/srep28899

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Copyright © 2016, Macmillan Publishers Limited

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(A) Representative traces of APs elicited at rheobase and twice rheobase in Dil-labeled joint sensory neurons from control (Ctrl) and AIA mice. mBSA challenge caused a reduction in rheobase while increasing the number of APs evoked by a 2x rheobase current injection. (B) Joint sensory neurons from AIA mice exhibited a more depolarized resting membrane potential (RMP), lower mean rheobase, and greater number of action potentials at 2X rheobase, as compared to the control group. No significant difference in input resistance (R_in) was observed between groups. Cell numbers tested are indicated in parentheses. *p < 0.05, **p < 0.001 versus control animals, unpaired t-test.