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. 2016 Jul 1;6:29020. doi: 10.1038/srep29020

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Copyright © 2016, Macmillan Publishers Limited

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Antioxidants can strongly inhibit cell death after LP treatment in HCT116 wild-type and HCT116 p53^−/− cells (A) and in HeLa cells (B). Cells were pretreated with MnTBAP, N-acetylcysteine (NAC), reduced glutathione (GSH), or the pan-caspase inhibitor zVAD for 1 h before LP treatment. Cell viability was monitored by the live/dead assay. (C) Ebselen - a mimetic of glutathione peroxidase (GPX1) - abrogates HeLa cell death after LP treatment. Ebselen was added to HeLa cells 1 h prior to treatment with LP for 24 h, the cell viability was measured by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. NS, not significant; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.