Table 2.
Transcription Factor-Binding Sites Significantly Overrepresented Among Genes Up- or Down-Regulated by Maternal or Fetal Infusion of TCS
| Transcription Factor | Site | Genes/Total | Adjusted Probability | |
|---|---|---|---|---|
| Up-regulated by TCSF infusion | ||||
| 1 | SP1 | hsa_GGGCGGR_V$SP1_Q6 | 265/2891 | 9.87 e-57 |
| 2 | ELK1 | hsa_SCGGAAGY_V$ELK1_O2 | 160/1176 | 8.13 e-55 |
| 3 | NRF1 | hsa_RCGCANGCGY_V$NRF1_Q6 | 121/894 | 1.03 e-40 |
| 4 | FOX04 | hsa_TTGTTT_V$FOX04_O1 | 157/2037 | 5.28 e-24 |
| 5 | NFY | hsa_GATTGGY_V$NFY_Q6_O1 | 101/1141 | 3.56 e-19 |
| 6 | GABP | hsa_MGGAAGTG_V$GABP_B | 76/744 | 9.21 e-18 |
| 7 | unknown | hsa_TGCGCANK_unknown | 63/537 | 1.2 e-17 |
| 8 | NFAT | hsa_TGGAAA_V$NFAT_Q4_O1 | 133/1871 | 2.5 e-17 |
| 9 | LEF1 | hsa_CTTTGT_V$LEF1_Q2 | 136/1939 | 2.64 e-17 |
| 10 | MYC | hsa_CACGTG_V$MYC_Q2 | 86/1015 | 2.55 e-15 |
| T3R | hsa_V$T3R_Q6 | 17/248 | 0.0048 | |
| ERR1 | hsa_TGACCTTY_V$ERR1_Q2 | 73/1023 | 8.99 e-10 | |
| ERR1 | hsa_V$ERR1_Q2 | 20/257 | 0.0007 | |
| ER | hsa_V$ER_Q6_O2 | 16/251 | 0.011 | |
| ER | hsa_V$ER_Q6_O1 | 16/264 | 0.0159 | |
| GR | hsa_V$GR_O1 | 19/202 | 9.76 e-5 | |
| GR | hsa_V$GR_Q6 | 17/267 | 0.009 | |
| GRE | hsa_V$GRE_C | 9/124 | 0.0255 | |
| LXR | hsa_V$LXR_Q3 | 8/74 | 0.005 | |
| PPARG | hsa_V$PPARG_O1 | 8/46 | 0.0003 | |
| PPAR | hsa_V$PPAR_DR1_Q2 | 17/257 | 0.0066 | |
| Down-regulated by TCSF infusion | ||||
| 1 | SP1 | hsa_GGGCGGR_V$SP1_Q6 | 319/2891 | 1.04 e-94 |
| 2 | MAZ | hsa_GGGAGGRR_V$MAZ_Q6 | 212/2250 | 9.23 e-49 |
| 3 | MYC | hsa_CACGTG_V$MYC_Q2 | 135/1015 | 1.92 e-46 |
| 4 | LEF1 | hsa_CTTTGT_V$LEF1_Q2 | 185/1939 | 4.6 e-43 |
| 5 | E12 | hsa_CAGCTG_V$E12_Q6 | 201/2450 | 2.06 e-37 |
| 6 | ELK1 | hsa_SCGGAAGY_V$ELK1_O2 | 130/1176 | 3.5 e-36 |
| 7 | FOX04 | hsa_TTGTTT_V$FOX04_O1 | 167/2037 | 1.11 e-30 |
| 8 | NRF1 | hsa_RCGCANGCGY_V$NRF1_Q6 | 103/894 | 5.75 e-30 |
| 9 | PAX4 | hsa_GGGTGGRR_V$PAX4_O3 | 125/1278 | 1.17 e-29 |
| 10 | SREBP1 | hsa_TCANNTGAY_V$SREBP1_O1 | 72/466 | 1.19 e-28 |
| ERR1 | hsa_TGACCTY_V$ERR1_Q2 | 106/1023 | 4.24 e-27 | |
| ERR1 | hsa_V$ERR1_Q2 | 32/257 | 9.22 e-11 | |
| ER | hsa_V$ER_Q6_O1 | 29/264 | 9.70 e-9 | |
| ER | hsa_V$ER_Q6 | 26/273 | 7.32 e-7 | |
| ER | hsa_V$GR_Q6_O2 | 22/251 | 1.53 e-5 | |
| GR | hsa_V$GR_Q6_O1 | 22/276 | 5.88 e-5 | |
| GR | hsa_V$GR_Q6 | 20/267 | 0.0003 | |
| GR | hsa_V$GR_O1 | 14/202 | 0.0038 | |
| GRE | hsa_V$GRE_C | 9/124 | 0.0138 | |
| PPAR | hsa_V$PPAR_DR1_Q2 | 24/257 | 2.53 e-6 | |
| PPARA | hsa_V$PPARA_O2 | 10/127 | 0.0057 | |
| PPARG | hsa_V$PPARG_O1 | 5/46 | 0.0138 | |
| T3R | hsa_V$T3R_Q6 | 19/248 | 0.0003 | |
| LXR | hsa_V$LXR_DR4_Q3 | 8/91 | 0.0069 | |
| LXR | hsa_V$LXR_Q3 | 7/74 | 0.0076 | |
| Up-regulated by TCSM infusion | ||||
| 1 | SP1 | hsa_GGGCGGR_V$SP1_Q6 | 152/2891 | 2.11 e-35 |
| 2 | MAZ | hsa_GGGAGGRR_V$MAZ_Q6 | 115/2250 | 5.15 e-25 |
| 3 | E12 | hsa_CAGGTG_V$E12_Q6 | 105/2450 | 4.56 e-17 |
| 4 | NRF1 | hsa_RCGCANGCGY_V$NRF1_Q6 | 56/894 | 1.88 e-15 |
| 5 | FOX04 | hsa_TTGTTT_V$FOX04_O1 | 90/2037 | 1.88 e-15 |
| 6 | ELK1 | hsa_SCGGAAGY_V$ELK1_O2 | 65/1176 | 1.88 e-15 |
| 7 | E2F1 | hsa_V$ERF1_Q6 | 29/228 | 1.88 e-15 |
| 8 | LEF1 | hsa_CTTTGT_V$LEF1_Q2 | 86/1939 | 5.45 e-15 |
| 9 | E2F1 | hsa_V$ERF1_Q3 | 29/240 | 5.45 e-15 |
| 10 | ETS2 | hsa_RYTTCCTG_V$ETS2_B | 58/1074 | 2.08 e-13 |
| ERR1 | hsa_TGACCTY_V$ERR1_Q2 | 29/1023 | 0.009 | |
| GR | hsa_V$GR_Q6 | 13/267 | 0.00019 | |
| GRE | hsa_V$GRE_C | 7/124 | 0.0111 | |
| GR | hsa_V$GR_O1 | 9/202 | 0.0149 | |
| GR | hsa_V$GR_Q6_O1 | 10/276 | 0.0308 | |
| PPAR | hsa_V$PPAR_DR1_Q2 | 12/257 | 0.0040 | |
| PPARA | hsa_V$PPARA_O2 | 7/127 | 0.0121 | |
| ER | None | |||
| PPARG | None | |||
| T3R | None | |||
| LXR | None | |||
| Down-regulated by TCSM infusion | ||||
| 1 | SP1 | hsa_GGGCGGR_V$SP1_Q6 | 162/2891 | 1.17 e-43 |
| 2 | E12 | hsa_CAGGTG_V$E12_Q6 | 117/2450 | 2.64 e-24 |
| 3 | ERR1 | hsa_TGACCTY_V$ERR1_Q2 | 72/1023 | 9.61 e-24 |
| 4 | NFAT | hsa_TGGAAA_V$NFAT_Q4_O1 | 95/1871 | 2.1 e-21 |
| 5 | MYC | hsa_CACGTG_V$MYC_Q2 | 68/1015 | 2.35 e-21 |
| 6 | LEF1 | hsa_CTTTGT_V$LEF1_Q2 | 94/1939 | 6.14 e-20 |
| 7 | unknown | hsa_AACTTT_unknown | 90/1859 | 4.81 e-19 |
| 8 | NFY | hsa_GATTGGY_V$NFY_Q6_O1 | 65/1141 | 6.46 e-17 |
| 9 | ELK1 | hsa_SCGGAAGY_V$ELK1_O2 | 66/1176 | 6.52 e-17 |
| 10 | AP4 | hsa_CAGCTG_V$AP4_Q5 | 75/1502 | 1.55 e-16 |
| ERR1 | hsa_V$ERR1_Q2 | 21/257 | 2.16 e-8 | |
| ER | hsa_V$ER_Q6_O1 | 14/264 | 0.0004 | |
| ER | hsa_V$ER_Q6 | 13/273 | 0.0015 | |
| ER | hsa_V$GR_Q6_O2 | 12/251 | 0.0019 | |
| GR | hsa_V$GR_Q6 | 11/267 | 0.0078 | |
| GR | hsa_V$GR_O1 | 8/202 | 0.0249 | |
| GRE | hsa_V$GRE_C | 6/124 | 0.023 | |
| T3R | hsa_V$T3R_Q6 | 10/248 | 0.0121 | |
| PPAR | hsa_V$PPAR_DR1_Q2 | 13/257 | 0.001 | |
| PPARA | hsa_V$PPARA_O2 | 7/127 | 0.0084 | |
| LXR | hsa_V$LXR_DR4_Q3 | 10/91 | 1.38 e-5 | |
| LXR | hsa_V$LXR_Q3 | 7/74 | 0.0007 | |