Figure 8. Phenotypic summary of the Kiss1^−/−, Kiss1r^−/−, Kiss1r^−/−Tg mice Gnaq^d/d;Gna11^−/− mice and cartoon illustrating the central and peripheral kisspeptin/KISS1R signaling pathways that potentiate endometrial gland development in the adult female mouse.

It is important to note that while activin A might be one of the centrally-stimulated peripheral factors that induces kisspeptin-dependent adenogenesis, other factors might also exist. Additionally, although there is unambiguous evidence that kisspeptin-dependent adenogenesis is positively regulated by peripheral kisspeptin signaling, where this signaling is localized is currently unknown.