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. 2016 Jun 10;48(6):e238. doi: 10.1038/emm.2016.37

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Ectopic overexpression of RBP2 in two RCC cell lines SKRC-39 and SN12C, induced an EMT program. (a) Western blotting assessment of elevated expression of RBP2 protein in RCC cell lines stably transfected with pCDNA-RBP2 in comparison with cells transfected with empty vector alone. (b) Cells with high RBP2 show reduced expression of the epithelial marker E-cadherin and elevated levels of the mesenchymal markers N-cadherin and vimentin. (c) mRNA expression of EMT factors analyzed by RT-PCR. (d) The ChIP assay shows that RBP2 is a DNA binding protein that can directly bind to the promoter sequence of E-cadherin DNA. RT-PCR, PCR with reverse transcription.