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. 2016 Jun 10;48(6):e238. doi: 10.1038/emm.2016.37

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Exogenous overexpression of RBP2 did not affect cell proliferation but promoted resistance to apoptosis in RCC cell lines SKRC-39 and SN12C. (a) MTT assay shows no change in proliferation rates of RBP2-transfected cells. (b) FACS DNA content analysis for the cell cycle profile of RBP2 expressing cells and control cells. (c) Quantification of apoptotic cells from DNA contents shows a reduced apoptotic population in RBP2-transfected cells. (d) Western blot analysis of proliferating cell nuclear antigen, Bcl-2 and Bax proteins indicating resistance to apoptosis but no change in proliferation of RBP2-transfected cells. (e) ChIP assay indicates binding of RBP2 to the Bcl-2 promoter.