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. 2016 Jun 17;48(6):e240. doi: 10.1038/emm.2016.39

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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PLC-β3 is required for retinal angiogenesis. (a) Retinas isolated from WT and PLC-β3 knockout mice at P6 were stained with IB4 (green), and angiogenesis was analyzed by measuring area and distance. Images were captured on confocal microscope at × 2.5 (zoom × 0.5). Scale bar, 800 μm. (b) P6 stage of retinas from WT and PLC-β3-deficient mice were stained with IB4 (green). Tip cells (upper) and filopodia (lower) were counted. Images were visualized on confocal microscope at × 40 (tip cells) and × 80 (filopodia) magnification. Scale bar, 100 μm. Angiogenic area (n=6), sprouting distance (n=24), tip cell number (n=6) and filopodia number (n=8) were quantified using Image J (National Institutes of Health) software. Data are means±s.e.m. Asterisks indicate statistical significance (P<0.05).